Guildrun Poison - Rules, Items and Counters

How Poison works

A permanent-for-the-fight stacking debuff that deals 1 damage per stack every 2 seconds.

Items that use Poison

Item	Classification	Relevant effect or role
Ring of the Leech	Epic	+22 Crit , +10 HP/s Whenever an enemy takes Poison damage, gain 1 Crit and 1 HP/S .
Ring of Virality	Epic	+300 Max HP , +6 Mana Regen Quest: Inflict 175 Poison Reward: Whenever the holder inflicts Poison, inflict 50 % more.
Toxic Contract	Rare	+15 Crit , +4 Mana Regen Quest: Inflict 100 Poison . Reward: Whenever the holder inflicts Poison, inflict 33 % more.
Toxic Dart	Rare	+15 Crit , +20 Attack Speed On Crit, inflict 3 Poison .
Toxic Gauntlet	Unique	+30 Defense Every 3 times the holder is auto attacked, inflict 1 Poison on the attacker.
Toxic Ring	Unique	+15 Defense , +7 Crit Quest: Inflict 25 Poison . Reward: Gain 10 Shards .
Toxic Shiv	Unique	+15 Crit On Crit, inflict 1 Poison .
Venomous Gauntlets	Epic	+200 Max HP , +30 Defense , +20 Attack Speed On auto attack, inflict 1 Poison on the target. When auto attacked, inflict 1 Poison on the attacker.

Relics that use Poison

Relic	Classification	Relevant effect or role
Assassin's Ambush Engine	Legendary	Heroes gain 30 Crit . Whenever an Assassin auto attacks while Stealthed , they inflict Poison on their target equal to 75 % of their Crit . At start of combat, Assassins in the back 2 rows gain Stealth for 5 seconds and target the most threatening enemy.
Blight Resonance Prism	Epic	Whenever an enemy takes Poison or Burn damage, heal all adjacent Heroes to them for 50 % of that damage.
Deceleration Corruptor	Epic	After Stall ( 15 ) and Stall ( 30 ), double the amount of Poison on all enemies.
Duelist's Rhythm Prism	Epic	Whenever a Duelist auto attacks, they randomly inflict 2 Poison , 4 Frost , or 6 Burn on their target.
Duelist's Toxin Banner	Unique	Whenever a Duelist auto attacks, they inflict 1 Poison on their target.
Plague Ascendancy	Epic	Quest: Inflict 25 Poison , 50 Frost , and 75 Burn on a single enemy. Reward: At start of Combat, inflict 25 Poison , 50 Frost , and 75 Burn on all enemies.
Plague Bauble	Unique	At start of combat, inflict 3 Poison , 6 Frost , and 9 Burn on all enemies.
Plague Generator	Common	At start of combat, inflict 5 Poison , 10 Frost , and 15 Burn on all enemies.
Plague Transmission Engine	Legendary	At start of combat and every 10 seconds, inflict 10 Poison , 20 Frost , and 30 Burn on all enemies.
Poison Accumulator	Unique	Quest: Inflict 50 Poison . Reward: Gain 15 Shards .
Poison Amplifier	Rare	Whenever a Hero inflicts Poison , inflict 33 % more.
Poison Ascendancy	Epic	Quest: Inflict 400 Poison . Reward: The first time each enemy reaches 50 Poison , they lose 33 % Max HP , 66 % Attack , and 66 % Attack Speed .
Poison Bauble	Unique	At start of combat, inflict 5 Poison on all enemies.
Poison Bloom	Common	After Stall ( 10 and Stall 20 ), inflict 10 Poison on all enemies.
Poison Catalyst	Rare	After Stall ( 15 ), whenever an enemy with Poison is auto attacked, they take damage equal to their Poison .
Poison Conduit	Rare	Quest: Inflict 200 Poison . Reward: Whenever a Hero inflicts Poison, they gain 1 Magic and 1 Attack per 2 Poison inflicted.
Poison Dragon's Venom	Act Boss	At start of combat, inflict 12 Poison on all Heroes. On combat victory, permanently increase the amount of Poison this inflicts by 2 .
Poison Migrator	Epic	Whenever an enemy dies, transfer their Poison to the nearest enemy.
Poison Vessel	Common	Quest: Inflict 100 Poison . Reward: Heroes gain 20 Attack Speed and 15 Crit .
Tank's Memento	Rare	At start of combat, inflict 20 Poison on all enemies per Tank in combat.
Tank's Poisonplate Banner	Unique	Whenever a Tank is auto attacked, they apply 1 Poison to the attacker.
Venom Amplification Engine	Legendary	Whenever an enemy takes 50 or more damage from Poison , they also take damage equal to 4 % of their Max HP .
Venom Precision Prism	Epic	Whenever an enemy takes Poison damage, Heroes gain 2 Crit .

Heroes that create or scale Poison

Hero	Classification	Relevant effect or role
Dragomir	Assassin	Gain 1 (+ 10% Crit ) Omnivamp , then deal 250 (+ 200% Magic , + 1000% Omnivamp ) damage. On kill, gain 2 (+2 per rank ) Shards .
Gustav	Mystic	Create a Blizzard for 5 seconds. Each second, inflict 1 (+ 1 per 8 Mana Regen ) Frost and deal 10 (+ 50% Magic ) damage to enemies inside the Blizzard. Shield Heroes inside it for 10 (+ 75% Magic ) .
Hoyoung	Assassin	Fire an arrow at the farthest enemy. It deals 250 (+ 250% Attack , + 250% Magic ) damage and gains 100% Crit + 50% Rank additional Crit .
Irini	Duelist	Each auto attack, gain 1 Attack Speed . After Stall ( 15 ), auto attacks deal 100% Attack Speed bonus damage .
Kai	Warrior	Charge up a mighty attack, gaining 300 (+ 400% Attack , + 250% Magic ) Shields . After 2 seconds, deal 100 (+ 100% Attack ) damage plus bonus damage equal to Kai's remaining Shields to surrounding enemies.
Karsu	Duelist	Loose a volley of 5 arrows at nearby enemies. Each arrow deals 25 (+ 100% Attack , + 100% Magic ) damage and inflicts 4 (+ 1 per 15 Attack Speed ) Frost .
Niklas	Vanguard	When Niklas survives combat, consume the item in his left-most item slot. Permanently gain 100 % of its stats and gain Shards equal to 80 % its value . For Rush ( 14 ), auto attacks inflict 1 (+ 1 per 500 Max Health ) Burn per equipped item.
Nyx	Duelist	For Rush ( 5 ), gain 5 (+ 25% Attack Speed ) Attack Speed and 5 (+ 25% Attack ) Attack for each time this ability has triggered this combat. Every 12 auto attacks, refresh all of Nyx's Rush abilities.
Pimenta	Tank	Create a poison cloud around Pimenta for 4 seconds. Each second, deal 5 (+ 50% Magic , + 50% Defense ) damage and inflict 2 (+ 1 per 25 Defense ) Poison to enemies in the poison cloud. Each second after Stall ( 15 ), gain 3 (+2 per rank ) HP/S per enemy in the poison cloud.
Pollen	Mystic	Create a flower field for 5 seconds. Each second, inflict 1 (+ 1 per 8 Mana Regen ) Poison on enemies and apply 10 (+ 100% Magic ) Shields to Heroes inside the flower field. Each second after Stall ( 15 ), heal Heroes inside the flower field for 10 (+ 50% Magic ) .
Ratna	Mage	Conjure celestial magic to deal 190 + 150 | 250 | 450 | 750% Magic damage. On kill, permanently gain 10 (+10 per rank ) Magic . On Crit, Stun all enemies for .5 (+.5 per rank ) seconds.
Reyna	Warrior	Unleash a 3 -punch combo. Each punch counts as an auto attack that deals 100 (+ 100% Attack , + 50% Magic ) % damage (Max: 500 %) and gives Reyna lasting Shields equal to 33 % of the damage dealt.
Rip	Vanguard	For Rush ( 10 ), gain 5% Max Health Attack . Whenever Rip or an enemy adjacent to him first drops below 50 % Max HP , refresh all of his Rush abilities and gain 2% Max Health Attack Speed .
Rowan	Vanguard / Tank	After Stall ( 10 ), gain 2 (+ 1 per 100 Max Health , + 1 per 15 Defense ) HP/S .
Sal	Mage	Sal empowers her attacks, causing them to also hit the nearest enemy to Sal's target, dealing 10 (+ 50% Magic ) bonus damage and inflicting 1 (+1 per rank ) Frost . This ability stacks.
Skorn	Tank	When auto attacked after Stall ( 10 ), deal 2 (+ 100% Magic ) damage and inflict 1 per 50 Defense Poison on the attacker.
Tilly	Warrior / Duelist	Gain 25% Attack Attack Speed and 25% Attack Speed Attack . Every 25 auto attacks, gain 2 (+2 per rank ) Shards .
Yuuna	Assassin	Leap into the air and throw 1 (+ 1 per 50 Crit ) shurikens at the lowest-health enemy for 150 (+ 150% Attack , + 150% Magic ) damage each. Max Shurikens: 8
Zuri	Tank / Assassin	On Crit, permanently gain 1 Defense and 1 Magic . Triggers 2 (+ 1 per 20 Crit , + 1 per 60 Defense ) times per combat.

Enemies related to Poison

Enemy	Classification	Relevant effect or role
Spider	Ranged	Inflict 25% Crit Poison on the farthest enemy and Stun them for 2 Seconds. Spiders start with 50 % Mana .
Snake	Melee	The Snake spits venom at its target, creating a trail of venom for 4 seconds. Each second, the venom trail deals 20 (+ 100% Attack ) damage and inflicts 1 (+ 10% Crit ) Poison .
Hydra	Melee	Deal 150% Attack damage and inflict 2 (+ 1 per 20 Attack ) Poison per remaining head.
Poison Dragon	Ranged	Deal 200 (+ 200% Magic ) damage and inflict 5 (+ 20% Magic ) Poison to all enemies.

How to use Poison in a run

Poison is a long-fight engine. Early application and effects that read total Poison matter more than a late one-time stack.

1. Check the trigger condition.Range, Crit, cast, target, Rush, Stall, and quest requirements decide whether the effect appears at all.
2. Check the first application.Timing can matter more than the final stack count, especially against an opening threat.
3. Separate trigger from amplifier.Confirm the team can create the effect before buying equipment that only improves it.